Controlled release from protein particles encapsulated by molecular layer deposition

Molecular layer deposition (MLD) was used to coat micron-sized protein particles in a fluidized bed reactor. Our results show that the dissolution rate of particles coated via MLD rapidly decreases with the increase in number of coating cycles, while the uncoated particles dissolve instantaneously....

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Published inChemical communications (Cambridge, England) Vol. 51; no. 63; pp. 1254 - 12543
Main Authors Vasudevan, Siddarth A, Xu, Yaolin, Karwal, Saurabh, van Ostaay, Helena G. M. E, Meesters, Gabriel M. H, Talebi, Mojgan, Sudhölter, Ernst J. R, Ruud van Ommen, J
Format Journal Article
LanguageEnglish
Published England The Royal Society of Chemistry 14.08.2015
Subjects
Chemistry
Coating
Controlled release
Delayed-Action Preparations
Deposition
Dissolution
Drug Carriers - chemistry
Encapsulation
Fluidized beds
Particle Size
Proteins
Proteins - chemistry
Proteins - metabolism
Reactors
Spectroscopy, Fourier Transform Infrared
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Summary:Molecular layer deposition (MLD) was used to coat micron-sized protein particles in a fluidized bed reactor. Our results show that the dissolution rate of particles coated via MLD rapidly decreases with the increase in number of coating cycles, while the uncoated particles dissolve instantaneously. Molecular layer deposition was applied for coating micron-sized protein particles to control their dissolution behaviour.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc03232f