Genome Sequences of Brucella melitensis 16M and Its Two Derivatives 16M1w and 16M13w, Which Evolved In Vivo

Brucella melitensis is an intracellular pathogen that induces chronic infection in humans. Here, we report the genome sequences of 16M and its two derivatives, 16M1w and 16M13w, which were allowed to adapt in vivo for 1 and 13 weeks, respectively. Our findings contribute to the investigation of adap...

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Bibliographic Details
Published inJournal of Bacteriology Vol. 194; no. 19; p. 5489
Main Authors Ke, Yuehua, Yuan, Xitong, Wang, Yufei, Bai, Yaoxia, Xu, Jie, Song, Hongbin, Huang, Liuyu, Chen, Zeliang
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.2012
Subjects
Animals
Bacterial infections
Bacteriology
Brucella melitensis
Brucella melitensis - classification
Brucella melitensis - genetics
Brucellosis - microbiology
Evolution, Molecular
genome
Genome Announcements
Genome, Bacterial
Genomes
Gram-negative bacteria
human diseases
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
nucleotide sequences
pathogens
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Summary:Brucella melitensis is an intracellular pathogen that induces chronic infection in humans. Here, we report the genome sequences of 16M and its two derivatives, 16M1w and 16M13w, which were allowed to adapt in vivo for 1 and 13 weeks, respectively. Our findings contribute to the investigation of adaptive mutations and mechanisms of chronic infection by B. melitensis.
Bibliography:http://dx.doi.org/10.1128/JB.01293-12
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Y.K., X.Y., Y.W., and Y.B. contributed equally to this work.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/JB.01293-12