Development of a reliable and reproducible phantom manufacturing method using silica microspheres in silicone

Optically scattering phantoms composed of silica microspheres embedded in an optically clear silicone matrix were manufactured using a previously developed method. Multiple problems, such as sphere aggregation, adsorption to the cast, and silicone shrinkage, were, however, frequently encountered. So...

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Bibliographic Details
Published inJournal of biomedical optics Vol. 22; no. 9; p. 095004
Main Authors Maughan Jones, Charlotte J, Munro, Peter R. T
Format Journal Article
LanguageEnglish
Published United States Society of Photo-Optical Instrumentation Engineers 01.09.2017
Subjects
Microspheres
Phantoms, Imaging
Reproducibility of Results
Silicon Dioxide
Silicones
optical scattering
spectrophotometry
phantoms
Mie theory
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Summary:Optically scattering phantoms composed of silica microspheres embedded in an optically clear silicone matrix were manufactured using a previously developed method. Multiple problems, such as sphere aggregation, adsorption to the cast, and silicone shrinkage, were, however, frequently encountered. Solutions to these problems were developed and an improved method, incorporating these solutions, is presented. The improved method offers excellent reliability and reproducibility for creating phantoms with uniform scattering coefficient. We also present evidence of decreased sphere aggregation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.22.9.095004