Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma

• Published in: Acta neuropathologica communications Vol. 5; no. 1; pp. 38 - 3
• Main Authors: López, Giselle, Oberheim Bush, Nancy Ann, Berger, Mitchel S, Perry, Arie, Solomon, David A
• Format: Journal Article
• Language: English
• Published: England BioMed Central 15.05.2017; BMC
• Subjects: Brain - diagnostic imaging; Brain - pathology; Brain - surgery; Brain cancer; Brain Neoplasms - diagnosis; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Classification; Diffuse Glioma; Eosinophilic Granular Body; Female; Glioma; Glioma - diagnosis; Glioma - genetics; Glioma - pathology; Glioma - therapy; Histones - genetics; Humans; IDH1 R132H; K27M Mutation; Kinases; Letter to the Editor; Midline Structure; Mutation; Pediatrics; Prognosis; Proteins; Spinal cord; Tumors; Young Adult
• ISSN: 2051-5960; 2051-5960
• DOI: 10.1186/s40478-017-0440-x

Authors' contributions MSB provided neurosugical management. NAOB provided neuro-oncology management. GL, AP, and DAS performed pathologic assessment. DAS performed genomic analysis. GL and DAS wrote the manuscript and created the figures. All authors read and approved the final manuscript. Competing interests D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403). The authors declare that they have no competing interests. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Additional files Additional file 1: Figure S1. Imaging features of the diffuse non-midline glioma, H3 K27M-mutant. Figure S2. Histologic features of the diffuse non-midline glioma with histone H3 K27M mutation. Figure S3. Genetic features of the diffuse non-midline glioma with histone H3 K27M mutation. (PDF 6168 kb)