Investigation of dynamic deformation of the midbrain in rear-end collision using human brain FE model

• Published in: Computer methods in biomechanics and biomedical engineering Vol. 23; no. 15; pp. 1236 - 1246
• Main Authors: Atsumi, Noritoshi, Iwamoto, Masami, Nakahira, Yuko, Asano, Yoshitaka, Shinoda, Jun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2020; Taylor & Francis Ltd
• Subjects: Acceleration; Accident reconstruction; Brain; Brain Concussion - pathology; Brain Concussion - physiopathology; Brain stem; Cognitive ability; Corpus callosum; Deformation; FEM; Finite Element Analysis; Finite element method; Head injuries; Humans; Intracranial Pressure; Mathematical models; Mesencephalon; Mesencephalon - pathology; Mesencephalon - physiopathology; midbrain; Models, Biological; Signs and symptoms; Stress, Mechanical; Traumatic brain injury; accident reconstruction; Traumatic brain injury; midbrain; brain stem; FEM
• ISSN: 1025-5842; 1476-8259
• DOI: 10.1080/10255842.2020.1795142

Mild traumatic brain injury (TBI), including concussions, can cause symptoms affecting physical or cognitive domains in the acute and chronic phases. In this study, we investigated the dynamic deformation of the brain stem, which might be important for these symptoms, using a human brain finite element model through reconstruction simulations of rear-end collisions in three different velocities. In all simulations, high maximum principal strain values were observed at the midbrain that were higher than those in the corpus callosum. These findings could provide some mechanical insights into brain disorders associated with mild TBI.