Recent Progress in Organocatalytic Asymmetric Domino Transformations

Sustainability in chemical synthesis is a major aspect of the current synthetic endeavors and, therefore, mimicking the biological process in the laboratory nowadays has the highest priority. Towards achieving this goal, designing organic reactions in domino mode rather than the multistep synthetic...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 360; no. 1; pp. 2 - 79
Main Authors Chanda, Tanmoy, Zhao, John C.‐G.
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 04.01.2018
Subjects
asymmetric synthesis
Asymmetry
Biological activity
Cascade chemical reactions
Catalysis
Chemical reactions
Chemical synthesis
diastereoselective synthesis
domino reactions
enantioselective synthesis
Natural products
organocatalysis
Reaction mechanisms
Sustainability
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Summary:Sustainability in chemical synthesis is a major aspect of the current synthetic endeavors and, therefore, mimicking the biological process in the laboratory nowadays has the highest priority. Towards achieving this goal, designing organic reactions in domino mode rather than the multistep synthetic pathways and using organocatalysis instead of metal catalysis have received a lot of attention due to the inherent advantages of these processes in terms of synthetic efficiency and sustainability. As a result, the field of asymmetric organocatalytic domino reactions has witnessed tremendous progress in recent years. This review attempts to summarize the latest developments in asymmetric organocatalyzed domino reactions since 2012, with the emphasis on the catalysts and reaction modes. Discussions on the reaction mechanisms and the applications of the developed domino reaction methods in the synthesis of biologically active molecules and natural products are also included when appropriate.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201701059