Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

• Published in: Advanced functional materials Vol. 30; no. 44
• Main Authors: Wankar, Jitendra, Kotla, Niranjan G., Gera, Sonia, Rasala, Swetha, Pandit, Abhay, Rochev, Yury A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.10.2020
• Subjects: Biocompatibility; Biodegradability; Biomedical engineering; Biomedical materials; Biosensors; Chain branching; cyclodextrin; Cyclodextrins; cyclodextrin‐grafting; cyclodextrin‐molecular machine; Diagnostic software; Diagnostic systems; drug delivery; Drug delivery systems; host–guest chemistry; Inclusion complexes; Materials science; medical device coating; Medical electronics; Medical equipment; Medical imaging; Molecular machines; stimulus responsive materials; Supramolecular compounds; Tissue engineering; Toxicity
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.201909049

This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host–guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of functional molecular machines such as polyrotaxane, polypseudorotaxane, and polycatenanes and grafting of cyclodextrin with different linear, branched chain polymers. The different stimuli‐based supramolecular assemblies involving cyclodextrin as a key mediator with linked triggering responses on payload release is highlighted. In addition, the applications of cyclodextrin in diagnostic imaging and medical devices is briefly demonstrated. Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio‐imaging. The toxicological profile of cyclodextrin is well established and safe for human consumption in food and medicine. An in‐depth overview of cyclodextrin's ability in terms of host–guest inclusion complexation is provided. Its detailed role in the fabrication of self‐assembled nanoparticles, molecular machines, polymer grafting, metal‐organic framework‐cyclodextrin, host–guest responsive biomaterials that exhibits the broad application in drug delivery, tissue engineering, and drug/contrast agent coated medical devices is described.