Coeliac disease-associated antibodies correlate with psoriasis activity

• Published in: British journal of dermatology (1951) Vol. 151; no. 4; pp. 891 - 894
• Main Authors: Woo, W.K., Mcmillan, S.A., Watson, R.G.P., Mccluggage, W.G., Sloan, J.M., Mcmillan, J.C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2004; Blackwell; Oxford University Press
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies - blood; Biological and medical sciences; Celiac Disease - immunology; Celiac Disease - pathology; coeliac disease-associated antibodies; Dermatology; duodenum; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gliadin - immunology; Humans; Immunoglobulin A - blood; Immunoglobulin G - blood; immunosuppressants; Immunosuppressive Agents - therapeutic use; Male; Medical sciences; Middle Aged; Other diseases. Semiology; psoriasis; Psoriasis - drug therapy; Psoriasis - immunology; Psoriasis. Parapsoriasis. Lichen; PUVA Therapy; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transglutaminases - immunology; Human; Skin disease; Duodenum; Psoriasis; Antibody; Dermatology; coeliac disease-associated antibodies; immunosuppressants; Gliadin; Immunosuppressive agent
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/j.1365-2133.2004.06137.x

Summary Background  Antigliadin antibodies (AGA) have been reported in patients with psoriasis. Objectives  To determine if AGA and other coeliac disease (CD)‐associated antibodies correlate with clinical features and activity in patients with psoriasis. Methods  Patients with psoriasis (n = 130) were investigated for serum IgG and IgA AGA, IgA antitransglutaminase antibody and IgA antiendomysial antibody. Disease characteristics and associated bowel and joint symptoms were determined. All patients were invited to undertake endoscopy with duodenal biopsy. Results  A significantly higher proportion of patients with elevated CD‐associated antibody levels was currently on or had previously required systemic immunosuppressants (methotrexate, ciclosporin or etretinate; P = 0·04) or psoralen plus ultraviolet A phototherapy (P = 0·03). One case of CD was diagnosed. Conclusions  The presence of CD‐associated antibodies in psoriasis patients correlates with greater disease activity.