Bone cement/layered double hydroxide nanocomposites as potential biomaterials for joint implant

• Published in: Journal of biomedical materials research. Part A Vol. 100A; no. 12; pp. 3363 - 3373
• Main Authors: Kapusetti, Govinda, Misra, Nira, Singh, Vakil, Kushwaha, R. K., Maiti, Pralay
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Aluminum Hydroxide - pharmacology; Apatite; Biocompatibility; Biocompatible Materials - pharmacology; Biological and medical sciences; Biomaterials; Biomedical materials; Body fluids; Bone biomaterials; bone cement; Bone cements; Bone Cements - pharmacology; Bone implants; Bone matrix; Calcium Hydroxide - pharmacology; Cell Line; Cement; fatigue; Fatigue strength; Grouting; Hemolysis - drug effects; Humans; Hydroxides; In vitro methods and tests; Joint Prosthesis; Joints (anatomy); Materials Testing; Mechanical Phenomena - drug effects; Mechanical properties; Medical sciences; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; nanocomposite; Nanocomposites; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Orthopedic surgery; Osteoblasts - cytology; Osteoblasts - drug effects; Polymers; Polymethyl methacrylate; Purchasing; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stiffness; Submerging; Surgeons; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical implants; Technology. Biomaterials. Equipments; Temperature; Thermal stability; Thermogravimetry; Thromboembolism; Thrombosis; X-Ray Diffraction; Osteoarticular system; Biological properties; bone cement; Implant; Layered double hydroxide; Biocompatibility; Fatigue; Biomaterial; Nanocomposite; Joint; Composite material; Biomedical engineering
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.34296

Poly(methyl methacrylate)‐based bone cement and layered double hydroxide (LDH) nanocomposites have been used as a grouting material for total joint arthroplasty. Few weight percentage of nanoLDH was uniformly dispersed in the bone cement matrix to have adequate interaction with matrix polymer. Mechanical strength, stiffness, toughness, and fatigue resistance of the nanocomposites are found to be higher than that of pure bone cement. Nanocomposites are thermally stable as compared to pristine bone cement. Direct mixing of the nanoLDH without any organic solvent makes these nanocomposites biocompatible. Biocompatibility was evaluated and compared with that of commercial bone cement by measuring hydrophilic nature, hemolysis assay, thrombosis assay, and deposition of apatite in simulated body fluid immersion. Finally, the viability of human osteoblast cells on the above developed nanocomposites was testified for actual biocompatibility. The experiment showed better cell growth in nanocomposites as compared to pure bone cement. Thus, these nanocomposites are found to be better grouting material than bone cement. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3363–3373, 2012.