Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution
Objective: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions. Method Etoposide solutions, 0·4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0·9% sodium chlor...
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Published in | Journal of clinical pharmacy and therapeutics Vol. 27; no. 2; pp. 139 - 142 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford UK
Blackwell Science Ltd
01.04.2002
Blackwell Hindawi Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions.
Method Etoposide solutions, 0·4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0·9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high‐performance liquid chromatography.
Results Substantial amounts of DEHP (up to 20 μg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0·9% sodium chloride injection and stored in the four different containers.
Conclusion To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container. |
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Bibliography: | ark:/67375/WNG-D6V76SJC-4 ArticleID:JCPT395 istex:7EFE0D2662E1AFAF0F77BAB0C62F53234C878685 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0269-4727 1365-2710 |
DOI: | 10.1046/j.1365-2710.2002.00395.x |