Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution

• Published in: Journal of clinical pharmacy and therapeutics Vol. 27; no. 2; pp. 139 - 142
• Main Authors: Demoré, B., Vigneron, J., Perrin, A., Hoffman, M. A., Hoffman, M.
• Format: Journal Article
• Language: English
• Published: Oxford UK Blackwell Science Ltd 01.04.2002; Blackwell; Hindawi Limited
• Subjects: Antineoplastic agents; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Biological and medical sciences; Chemotherapy; diethylhexyl phthalate (DEHP); Diethylhexyl Phthalate - chemistry; Drug Contamination; Drug Storage; etoposide; Etoposide - administration & dosage; Etoposide - chemistry; General pharmacology; HPLC; Humans; Infusions, Intravenous; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; polyvinyl chloride (PVC) bags; Polyvinyl Chloride - chemistry; Temperature; Antineoplastic agent; Delivery system; Amorphous material; Injectable form; Pharmaceutical technology; Intravenous administration; Conservation; Container content interaction; Glass; HPLC chromatography; Etoposide; In vitro; Podophyllotoxine derivatives; Storage; Packaging; Kinetics; Polyvinyl chloride; Pharmacokinetics; Antimitotic; Release; Quantitative analysis
• ISSN: 0269-4727; 1365-2710
• DOI: 10.1046/j.1365-2710.2002.00395.x

Objective: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions. Method Etoposide solutions, 0·4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0·9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high‐performance liquid chromatography. Results Substantial amounts of DEHP (up to 20 μg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0·9% sodium chloride injection and stored in the four different containers. Conclusion To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.