Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children
Summary objective To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. patients One hundred and two boys, 13·6–15·5 years of age, who were referred because of short stature and delayed puberty. methods The boys were randomly allocated to...
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Published in | Clinical endocrinology (Oxford) Vol. 60; no. 6; pp. 682 - 687 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.06.2004
Blackwell Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
objective To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children.
patients One hundred and two boys, 13·6–15·5 years of age, who were referred because of short stature and delayed puberty.
methods The boys were randomly allocated to one of the following treatment groups: oxandrolone therapy, 5 mg/day for 6 months (n = 15), testosterone depot, 100 mg monthly for 3 months (n = 15) or for 6 months (n = 20), nutritional programme (n = 17), oxandrolone and nutritional programme (n = 15) or passive observation (n = 20). Boys in the nutritional programmes received 12 mg/day iron and 6000 IU/week of vitamin A. Outcome measurements were of height, weight, pubertal signs, dietary intake, serum vitamin A, iron, GH and IGF‐1.
results Six months of vitamin A supplementation induced growth acceleration similar to that seen in the oxandrolone‐ and testosterone‐treated children, and significantly greater than in the observation group (9·3 ± 2·9 vs. 4·0 ± 0·9 crn/yr, P < 0·001). Whereas in the vitamin A‐supplemented group, puberty (increase in testicular volume ≥ 12 ml) was induced within 12 months. In all testosterone‐treated patients, pubic hair was noted within 3 months and a testicular volume of ≥ 12 ml was observed 9–12 months after the initiation of therapy. No pubertal signs were noted in the observation group during this time.
conclusions Subnormal vitamin A intake is one of the aetiological factors in delayed pubertal maturation. Supplementation of both vitamin A and iron to normal constitutionally delayed children with subnormal vitamin A intake is as efficacious as hormonal therapy in the induction of growth and puberty. |
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Bibliography: | ArticleID:CEN2034 ark:/67375/WNG-9TWP3BR7-2 istex:098DBC3FF41E67F295499A233F8982BDC9F0299D ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
ISSN: | 0300-0664 1365-2265 |
DOI: | 10.1111/j.1365-2265.2004.02034.x |