A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, a...

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Bibliographic Details
Published inCase Reports in Hepatology Vol. 2020; no. 2020; pp. 1 - 4
Main Authors Inamdar, Kedar V., Gordon, Stuart C., Husain, Sanam, Maahs, Lucas, Columbus-Morales, Ivan, Gonzalez, Humberto C.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 20.08.2020
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Abdomen
Acquired immune deficiency syndrome
AIDS
Antigens
Autoimmune diseases
Biopsy
Bone marrow
Case Report
Case reports
Cytokines
Cytotoxicity
Fever
Fungal infections
Gallbladder
Health aspects
Histoplasmosis
HIV
Human immunodeficiency virus
Infection
Infectious diseases
Inflammation
Laboratories
Liver
Lymphatic diseases
Medical colleges
Methenamine
Mortality
Multiple organ dysfunction syndrome
Patients
Phosphatase
Posaconazole
Resveratrol
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Summary:Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, and infections, such as histoplasmosis. Histoplasmosis commonly has subclinical manifestations but can also present in its disseminated form. We present the case of an immunocompromised patient with worsening liver function caused by hepatic histoplasmosis that later triggered HLH with severe multiorgan dysfunction.
Bibliography:Academic Editor: Sorabh Kapoor
ISSN:2090-6587
2090-6595
DOI:10.1155/2020/6901514