Hydrolytic Enzymes (Acid Phosphatase and Beta-glucuronidase) in Cultured Brain Tumors

A histochemical study of hydrolytic enzymes such as acid phosphatase and beta-glucuronidase was made on cultured brain tumor cells. Well-differentiated astrocytic cells, oligodendroglioma cells, and medulloblastoma cells showed low activities. Migrating cells and macrophage-like cells showed intense...

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Bibliographic Details
Published inNeurologia medico-chirurgica Vol. 24; no. 7; pp. 453 - 458
Main Authors KAMITANI, Hiroshi, MASUZAWA, Hideaki, SATO, Jinichi, OKADA, Michio
Format Journal Article
LanguageEnglish
Published Japan The Japan Neurosurgical Society 1984
Subjects
acid phosphatase
Acid Phosphatase - metabolism
Brain - enzymology
brain neoplasms
Brain Neoplasms - enzymology
Culture Techniques
glucuronidase
Glucuronidase - metabolism
Humans
Neurons - enzymology
tissue culture
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Summary:A histochemical study of hydrolytic enzymes such as acid phosphatase and beta-glucuronidase was made on cultured brain tumor cells. Well-differentiated astrocytic cells, oligodendroglioma cells, and medulloblastoma cells showed low activities. Migrating cells and macrophage-like cells showed intense activities. Meningioma cells and schwannoma cells showed relatively intense activities at the early stage of cultivation. At the aged stage, the former showed a characteristic pattern of reaction products. The intensity and distribution of beta-glucuronidase were similar to those of acid phosphatase in cultured brain tumors. The relationship of hydrolytic enzymes to cellular differentiation and viability was discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0470-8105
1349-8029
DOI:10.2176/nmc.24.453