Psychosis Following an Increase in Intrathecal Baclofen

Abstract Baclofen is a commonly used medication to treat spasticity in neurologic disorders. In the traumatic brain injury population, the intrathecal administration of baclofen is often preferred over oral administration due to cognitive side effects. Here we report on a case of a psychotic episode...

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Bibliographic Details
Published inPM & R Vol. 8; no. 12; pp. 1222 - 1224
Main Authors Maneyapanda, Mithra B., MD, Patel Driver, Sangeeta, MD MPH, Ripley, David L., MD MS, Lloyd, Robert, MD, PhD, Brkic, Nenad, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2016
Subjects
Baclofen
Brain Injuries, Traumatic
Humans
Injections, Spinal
Male
Muscle Relaxants, Central
Muscle Spasticity
Physical Medicine and Rehabilitation
Psychotic Disorders
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Summary:Abstract Baclofen is a commonly used medication to treat spasticity in neurologic disorders. In the traumatic brain injury population, the intrathecal administration of baclofen is often preferred over oral administration due to cognitive side effects. Here we report on a case of a psychotic episode following an increase in intrathecal baclofen in a young man with a history of a traumatic brain injury (TBI). While intrathecal baclofen is commonly used and generally well tolerated, this case highlights an important potential effect of intrathecal baclofen, rarely reported in the literature.
Bibliography:Disclosures outside this publication: consultancy, iHuman
Disclosure: nothing to disclose
Disclosures outside this publication: expert testimony, multiple expert opinion, and testimony on cases involving traumatic brain injury (money to institution); payment for lectures including service on speakers bureaus, Royal Hospital for Neurodisability (money to institution)
ObjectType-Case Study-2
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ObjectType-Report-1
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ISSN:1934-1482
1934-1563
DOI:10.1016/j.pmrj.2016.06.018