Dynamic impact of inflammation-based indices in colorectal cancer patients receiving FOLFOX-based chemotherapy

• Published in: Cancer management and research Vol. 11; pp. 2817 - 2829
• Main Authors: Tao, Yong, Yuan, Danping, Pang, Hongshuang, Wu, Hongbiao, Liu, Dongfang, Jin, Ningning, Wu, Ningning, Qiu, Jianming, Cao, Yuepeng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.04.2019; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Analysis; Biomarkers; Blood platelets; Cancer patients; Cancer treatment; Care and treatment; Chemotherapy; Colorectal cancer; Colorectal surgery; coNLR-PLR; Development and progression; FOLFOX-based chemotherapy; Hospitals; Inflammation; Lymphocytes; Medical prognosis; Medical research; neutrophil-to-lymphocyte ratio; Neutrophils; Original Research; platelet-to-lymphocyte ratio; Surgery; Systematic review; Tumors; China; platelet-to-lymphocyte ratio; coNLR-PLR; neutrophil-to-lymphocyte ratio; colorectal cancer; FOLFOX-based chemotherapy
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S191712

Inflammatory cellular response is implicated in the pathogenesis of colorectal cancer (CRC). Nevertheless, the dynamic effects of inflammatory index coNLR (neutrophil-to-lymphocyte ratio)-PLR (platelet-to-lymphocyte ratio) during chemotherapy remain elusive. The baseline clinical data and laboratory parameters of 480 CRC patients who received palliative resection of primary tumors and FOLFOX-based chemotherapy from January 2007 to January 2013 were retrospectively analyzed. Receiver operating characteristic curves were plotted to obtain the predictive NLR and PLR values, and to calculate the coNLR-PLR score. The Kaplan-Meier method was used to estimate the rates of recurrence-free survival (RFS) and overall survival (OS), and the Cox proportional hazards model was employed for analysis. The dynamic cut-off values of NLR during four periods of chemotherapy were 3.029, 2.466, 2.102 and 1.795, respectively, and those of PLR were 216.438, 187.572, 169.027 and 174.368, respectively. A higher coNLR-PLR was significantly associated with lower rates of RFS and OS ( <0.05). Both univariate and multivariate analyses showed that coNLR-PLR was a significant independent prognostic factor for RFS and OS ( <0.05). CoNLR-PLR was a significant prognostic predictor for CRC patients who received FOLFOX-based chemotherapy. Evaluating this index can accurately predict the clinical treatment outcomes after chemotherapy.