What Does Soluble C-Type Lectin-like Receptor 2 (sCLEC-2) × D-Dimer/Platelet (PLT) (sCLEC-2 × D-Dimer/PLT) Mean for Coagulation/Fibrinolysis Conditions? Comment on Yamamoto et al. Super Formula for Diagnosing Disseminated Intravascular Coagulation Using Soluble C-Type Lectin-like Receptor 2. Diagnostics 2023, 13, 2299

• Published in: Diagnostics Vol. 14; no. 1; p. 41
• Main Author: Ishikura, Hiroyasu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.12.2023; MDPI
• Subjects: Aortic aneurysms; Comment; Hematology; Lectins; Medicine (General); n/a; R5-920; Sepsis; Thromboembolism; Trauma
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics14010041

Additionally, sCLEC-2 concentrations are likely to be affected by the platelet count. [...]this level could remain low under a low platelet count and would not increase immediately. [...]my research group proposed calculating the sCLEC-2/platelet count ratio (called the C2PAC index) to determine sCLEC2 concentrations per platelet unit and considered this index an index of platelet activation [2]. In all underlying diseases, except for patients with unidentified clinical syndromes, patients with post-cardiopulmonary arrest showed different platelet counts, values of coagulation/fibrinolytic markers, and DIC scores compared with those with other underlying diseases (Table 1) [1]. The subject study protocol (2019-K9) was approved by the Human Ethics Review Committee of Mie Prefectural General Medical Center, and informed consent was obtained from each participant.