Humanized Mouse Models for Transplant Immunology

• Published in: American journal of transplantation Vol. 16; no. 2; pp. 389 - 397
• Main Authors: Kenney, L.L., Shultz, L.D., Greiner, D.L., Brehm, M.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2016; Elsevier Limited
• Subjects: Allografts; Animal models; Animals; basic (laboratory) research/science; cellular transplantation (non-islet); Disease Models, Animal; Drug development; experimental; Graft rejection; Graft Rejection - immunology; Graft Rejection - prevention & control; Humans; Immune response; Immunodeficiency; Immunology; Immunomodulation; Immunosuppressive agents; islet transplantation; Mice; Organ Transplantation; Prognosis; regenerative medicine; rejection; Rodents; stem cells; tolerance; translational research/science; Transplantation; Transplantation Immunology; Transplants & implants; animal models; regenerative medicine; experimental; GVHD; cellular transplantation (non-islet); BLT; scid, Prkdcscid; IFN-γ; ESC; Hu-SRC-SCID; anti-Gr1; IL2rgnull; PD-L1; CTLA4; HSC; TGF-β; islet transplantation; Rag2; tolerance; SCID/beige; stem cells; BAFF; NOD; translational research/science; NSG; NRG-Akita; Tregs; iPSC; NOG; Hu-PBL-SCID; PBMC; rejection; anti-GM1; MST; beige; UCB; BRG; basic (laboratory) research/science; NICC
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/ajt.13520

Our understanding of the molecular pathways that control immune responses, particularly immunomodulatory molecules that control the extent and duration of an immune response, have led to new approaches in the field of transplantation immunology to induce allograft survival. These molecular pathways are being defined precisely in murine models and translated into clinical practice; however, many of the newly available drugs are human-specific reagents. Furthermore, many species-specific differences exist between mouse and human immune systems. Recent advances in the development of humanized mice, namely, immunodeficient mice engrafted with functional human immune systems, have led to the availability of a small animal model for the study of human immune responses. Humanized mice represent an important preclinical model system for evaluation of new drugs and identification of the mechanisms underlying human allograft rejection without putting patients at risk. This review highlights recent advances in the development of humanized mice and their use as preclinical models for the study of human allograft responses.