Accelerated rejection following offspring‐to‐mother and husband‐to‐wife transplants

• Published in: Clinical transplantation Vol. 18; no. 6; pp. 729 - 733
• Main Authors: Rosenberg, Jerry C., Jones, Bruce, Oh, Henry
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.12.2004; Blackwell
• Subjects: accelerated rejection; Adult; anamnestic reaction; Biological and medical sciences; Cardiology. Vascular system; Female; Graft Rejection - etiology; Graft Rejection - immunology; Humans; husband‐to‐wife transplant; immunologic mechanisms of rejection; Kidney Transplantation - immunology; Living Donors; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nuclear Family; offspring‐to‐mother transplant; Time Factors; Graft(material); accelerated rejection; immunologic mechanisms of rejection; husband-to-wife transplant; Transplantation; Homotransplantation; Reaction; offspring-to-mother transplant; Mechanism; Rejection; Progeny; Treatment; Mother; Surgery; anamnestic reaction; Graft; Anesthesia; Circulatory system; Cardiology
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/j.1399-0012.2004.00250.x

:  It has been demonstrated that graft survival rates of offspring‐to‐mother and husband‐to‐wife renal transplants are equivalent to those of other living donors. Although the vast majority of these transplants proceed without incident, we have encountered several instances of delayed accelerated rejections that are not predicted by a positive cross‐match. The accelerated rejection can result from an anamnestic reaction subsequent to the in utero exposure of the mother to human leukocyte antigen (HLA) antigens of the fetus with sensitization developing during the pregnancy.