The Effects of Plasma Insulin and Glucose on Myocardial Blood Flow in Patients With Type 1 Diabetes Mellitus

• Published in: Journal of the American College of Cardiology Vol. 46; no. 1; pp. 42 - 48
• Main Authors: Srinivasan, Muthayyah, Herrero, Pilar, McGill, Janet B., Bennik, Jasper, Heere, Bastiaan, Lesniak, Donna, Davila-Roman, Victor G., Gropler, Robert J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.07.2005; Elsevier Limited
• Subjects: Adult; Aged; Atherosclerosis; Blood Glucose - physiology; Blood pressure; Cardiology; Cardiomyopathy; Cardiovascular disease; Coronary Circulation - physiology; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - diagnostic imaging; Diabetes Mellitus, Type 1 - physiopathology; Female; Glucose; Glucose Clamp Technique; Heart; Heart rate; Humans; Hyperglycemia; Hypotheses; Insulin; Insulin - physiology; Male; Middle Aged; Mortality; Plasma; Positron-Emission Tomography; Studies; Variance analysis; Vasodilation - physiology; HH; MBF; T1DM; T2DM; RPP; MBFa; MBFr; HbA1c; HE; MPR
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2005.03.056

The objective of this study was to determine the impact of insulin and glucose on myocardial vasodilator function in patients with type 1 diabetes mellitus (T1DM). The relative importance of plasma insulin and glucose levels on the abnormal vasodilator function observed in T1DM is unknown. Twenty T1DM patients underwent positron emission tomography studies to measure myocardial blood flow (MBF) (in ml/g/min) at rest (MBFr) and during adenosine (MBFa), both under baseline metabolic conditions and then during either hyperinsulinemic-euglycemic clamp (HE) (n = 10; 40 ± 9 years, 8 female subjects, hemoglobin A1c [HbA1c] 7.8 ± 1.1%) or hyperinsulinemic-hyperglycemic clamp (HH) (n = 10; 44 ± 12 years, 8 female subjects, hemoglobin A1c 7.7 ± 0.6%). Both groups showed similar MBFr and MBFa under baseline metabolic conditions (p = NS). Compared with baseline conditions, MBFr increased in the HH group (p < 0.005), whereas it did not change in the HE group. Compared with baseline conditions, MBFa decreased in the HH group (p < 0.05) but did not change in the HE group. Myocardial perfusion reserve (MPR) (MBFa /MBFr) was similar between the HE and HH groups at baseline (p = NS). During clamp, MPR tended to decrease in the HH group (p < 0.1) but did not change in the HE group (p = NS) when compared with baseline conditions. However, during the clamp MPR was significantly lower in the HH group when compared with the HE group (p < 0.0001). In the short term, hyperglycemia has a deleterious effect on myocardial vasodilator function, which outweighs the beneficial effect of hyperinsulinemia.