Prognostic Value of an Inflammation-Related Index in 6,865 Chinese Patients With Postoperative Digestive Tract Cancers: The FIESTA Study

• Published in: Frontiers in oncology Vol. 9; p. 427
• Main Authors: Zhang, Xinran, Hu, Dan, Lin, Xiandong, Zhang, Hejun, Xia, Yan, Lin, Jinxiu, Zheng, Xiongwei, Peng, Feng, Jie, Jianzheng, Niu, Wenquan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.05.2019
• Subjects: digestive tract cancer; FIESTA study; mortality; neutrophil-to-lymphocyte ratio; Oncology; platelet-to-lymphocyte ratio; prognosis; platelet-to-lymphocyte ratio; mortality; neutrophil-to-lymphocyte ratio; FIESTA study; digestive tract cancer; prognosis
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2019.00427

We sought to determine the optimal cutting points for two inflammatory biomarkers, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), to assess their prognostic value in patients with postoperative digestive tract cancers overall and by cancer sites, and further to construct an inflammation-related index based on the two biomarkers and assess its predictive performance. Total 6,865 assessable patients with digestive tract cancers who underwent tumor resection were consecutively enrolled from Fujian Cancer Hospital between January 2000 and December 2010, including 2535/3012/1318 patients with esophageal/gastric/colorectal cancer. The latest follow-up (median: 44.9 months) ended in December 2015. Optimal cutting points were determined using survival tree analysis overall and by cancer sites. Among all study patients, the optimal cutting points were 2.07 and 168.50 to define high and low NLR and PLR, respectively. High NLR (hazard ratio [HR]: 1.48, 95% confidence interval [CI]: 1.37-1.61) and high PLR (HR: 1.41, 95% CI: 1.29-1.53) were associated with a significantly increased risk for the mortality of digestive tract cancers as a whole. By cancer sites, effect-size estimates were comparable and statistically significant. Elevation over the selected optimal cutting points for both NLR and PLR was associated with 1.69-fold increased risk of cancer-specific mortality compared to patients with simultaneously low NLR and PLR among all study patients, and this association persisted by cancer sites, especially for gastric cancer. Our findings demonstrate that the preoperative integrated NLR and PLR, as an inflammation-related index, is a significant independent predictor for postoperative mortality in Chinese patients with digestive tract cancers both overall and by cancer sites.