Infections Caused by Antimicrobial Drug-Resistant Saprophytic Gram-Negative Bacteria in the Environment

• Published in: Frontiers in medicine Vol. 4; p. 183
• Main Authors: Raphael, Eva, Riley, Lee W.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.10.2017
• Subjects: drug-resistant Gram-negative bacteria; Enterobacter aerogenes; Gram-negative bacteria; Medicine; Pantoea agglomerans; Pseudomonas putida; saprophytes; Pantoea agglomerans; Enterobacter aerogenes; Gram-negative bacteria; saprophytes; Pseudomonas putida; drug-resistant Gram-negative bacteria
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2017.00183

Drug-resistance genes found in human bacterial pathogens are increasingly recognized in saprophytic Gram-negative bacteria (GNB) from environmental sources. The clinical implication of such environmental GNBs is unknown. We conducted a systematic review to determine how often such saprophytic GNBs cause human infections. We queried PubMed for articles published in English, Spanish, and French between January 2006 and July 2014 for 20 common environmental saprophytic GNB species, using search terms "infections," "human infections," "hospital infection." We analyzed 251 of 1,275 non-duplicate publications that satisfied our selection criteria. Saprophytes implicated in blood stream infection (BSI), urinary tract infection (UTI), skin and soft tissue infection (SSTI), post-surgical infection (PSI), osteomyelitis (Osteo), and pneumonia (PNA) were quantitatively assessed. Thirteen of the 20 queried GNB saprophytic species were implicated in 674 distinct infection episodes from 45 countries. The most common species included , and . Of these infections, 443 (66%) had BSI, 48 (7%) had SSTI, 36 (5%) had UTI, 28 (4%) had PSI, 21 (3%) had PNA, 16 (3%) had Osteo, and 82 (12%) had other infections. Nearly all infections occurred in subjects with comorbidities. Resistant strains harbored extended-spectrum beta-lactamase (ESBL), carbapenemase, and metallo-β-lactamase genes recognized in human pathogens. These observations show that saprophytic GNB organisms that harbor recognized drug-resistance genes cause a wide spectrum of infections, especially as opportunistic pathogens. Such GNB saprophytes may become increasingly more common in healthcare settings, as has already been observed with other environmental GNBs such as and .