Sensory MEG Responses Predict Successful and Failed Inhibition in a Stop-Signal Task

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 19; no. 1; pp. 134 - 145
• Main Authors: Boehler, C. N., Münte, T. F., Krebs, R. M., Heinze, H. -J., Schoenfeld, M. A., Hopf, J. -M.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2009; Oxford Publishing Limited (England)
• Subjects: Adult; Cerebral Cortex - physiology; Decision Making - physiology; executive function; Female; Humans; inhibition; Inhibition (Psychology); Magnetoencephalography - methods; Male; MEG; Neural Inhibition - physiology; posterior cingulate gyrus; Reaction Time - physiology; Signal Detection, Psychological - physiology; stop-paradigm; Task Performance and Analysis; visual attention; Visual Perception - physiology; visual attention; posterior cingulate gyrus; inhibition; stop-paradigm; MEG; executive function
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhn063

In the present study magnetoencephalographic recordings were performed to investigate the neural mechanisms underlying the stopping of manual responses. Subjects performed in a Stop-signal task in which Go-stimuli (S1), requiring a rapid motor response, were sometimes rapidly followed by a Stop-stimulus (S2) indicating to withhold the already initiated response to S1. Success of stopping strongly depended on the early perceptual processing of S1 and S2 reflected by the magnetic N1 component. Enhanced processing of S1 facilitated the execution of the movement, whereas enhanced processing of S2 favored its inhibition. This suggests that the processing resources for the subsequent stimuli are limited and need to be shared. This sharing of resources appeared to arise from adjustments made on a trial-by-trial basis, in that systematic reaction time prolongations on Go-trials following Stop-trials versus following Go-trials were accompanied by attenuated sensory processing to the Go-stimulus similar to that seen in successful versus unsuccessful stopping in Stop-trials.