Recent progress in the role of autophagy in neurological diseases
Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein aggregates and damaged organelles are first sequestered into a double-membraned structure called autophago-some and then delivered to lysosome for destruction. Recently, tremen-dous progress has been made to eluc...
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Published in | Cell Stress Vol. 3; no. 5; pp. 141 - 161 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Austria
Shared Science Publishers OG
29.04.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein aggregates and damaged organelles are first sequestered into a double-membraned structure called autophago-some and then delivered to lysosome for destruction. Recently, tremen-dous progress has been made to elucidate the molecular mechanism and functions of this essential cellular metabolic process. In addition to being either a rubbish clearing system or a cellular surviving program in response to different stresses, autophagy plays important roles in a large number of pathophysiological conditions, such as cancer, diabetes, and especially neurodegenerative disorders. Here we review recent progress in the role of autophagy in neurological diseases and discuss how dysregulation of autophagy initiation, autophagosome formation, maturation, and/or au-tophagosome-lysosomal fusion step contributes to the pathogenesis of these disorders in the nervous system. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Conflict of interest: The authors declare that they have no conflict of interests. Please cite this article as: Tian Meng, Shiyin Lin, Haixia Zhuang, Haofeng Huang, Zhengjie He, Yongquan Hu, Qing Gong and Du Feng (2019). Recent progress in the role of autophagy in neurological diseases. Cell Stress 3(5): 141-161. doi: 10.15698/cst2019.05.186 |
ISSN: | 2523-0204 2523-0204 |
DOI: | 10.15698/cst2019.05.186 |