Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States

• Published in: Journal of the American Heart Association Vol. 8; no. 3; p. e010995
• Main Authors: Zhang, Wangjian, Spero, Tanya L, Nolte, Christopher G, Garcia, Valerie C, Lin, Ziqiang, Romitti, Paul A, Shaw, Gary M, Sheridan, Scott C, Feldkamp, Marcia L, Woomert, Alison, Hwang, Syni-An, Fisher, Sarah C, Browne, Marilyn L, Hao, Yuantao, Lin, Shao
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 05.02.2019; Wiley
• Subjects: Adult; climate change; congenital heart defects; Female; Follow-Up Studies; Heart Defects, Congenital - epidemiology; Heart Defects, Congenital - etiology; Hot Temperature - adverse effects; Humans; Incidence; Infant, Newborn; Male; Maternal Exposure - adverse effects; maternal heat exposure; Original Research; Pregnancy; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects - epidemiology; projection; Retrospective Studies; Risk Assessment - methods; Risk Factors; Seasons; United States - epidemiology; United States; projection; maternal heat exposure; pregnancy; climate change; congenital heart defects
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.118.010995

Background More intense and longer-lasting heat events are expected in the United States as a consequence of climate change. This study aimed to project the potential changes in maternal heat exposure during early pregnancy (3-8 weeks post conception) and the associated burden of congenital heart defects ( CHD s) in the future. Methods and Results This study expanded on a prior nationwide case-control study that evaluated the association between CHD s and maternal heat exposure during early pregnancy in summer and spring. We defined multiple indicators of heat exposure, and applied published odds ratios obtained for the matching season of the baseline (1995-2005) into the projection period (2025-2035) to estimate potential changes in CHD burden throughout the United States. Increases in maternal heat exposure were projected across the United States and to be larger in the summer. The Midwest will potentially have the highest increase in summer maternal exposure to excessively hot days (3.42; 95% CI, 2.99-3.88 per pregnancy), heat event frequency (0.52; 95% CI, 0.44-0.60) and heat event duration (1.73; 95% CI, 1.49-1.97). We also found large increases in specific CHD subtypes during spring, including a 34.0% (95% CI, 4.9%-70.8%) increase in conotruncal CHD in the South and a 38.6% (95% CI , 9.9%-75.1%) increase in atrial septal defect in the Northeast. Conclusions Projected increases in maternal heat exposure could result in an increased CHD burden in certain seasons and regions of the United States.