Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

• Published in: The Journal of pediatrics Vol. 232; pp. 287 - 289.e4
• Main Authors: Villaverde, Serena, Domínguez-Rodríguez, Sara, Sabrido, Gema, Romero, María Pilar, Grasa, Carlos Daniel, Jiménez, Ana Belén, Heras, Elena, Núñez, María del Mar, Illán, Marta, Soto, Beatriz, Mendoza, Pablo, Gijón, Manuel, Pérez-Moneo, Begoña, Moraleda, Cinta, Tagarro, Alfredo, del Rosal, Teresa, Santos, Mar, Rincón, Elena, Santiago, Begoña, Saavedra-Lozano, Jesús, Aguilera-Alonso, David, Epalza, Cristina, Rojo, Pablo, Calleja, Gero, de la Torre, Mercedes, Sanz-Santaeufemia, F.J., Herrero, B., Alonso, M., Soriano-Arandes, Toni, Pujol, J.M., Soler-Palacin, Pere, Lanaspa, Miguel, Urretavizcaya, M., Herranz, Mercedes, Ara, Fatima, Cabañas, Santiago, Vázquez, José Luis, Falcón, Lola, Neth, Olaf, Goicoechea, Walter, Figueroa, Lucía, García, Claudia, Alvaredo, Teresa, Olmedo, Ma Inmaculada, López, Agustín, Cobo, Elvira, Galán, Pilar, Guillén, Sara, Navas, Adriana, Pérez, Sara, Hernández, María José, Berzosa, Arantxa, Ruiz, Beatriz, Alfayate, Santiago, Menasalvas, Ana, Cervantes, Eloísa, Méndez, María, Hurtado, Ángela, Oltra, Manuel, Villaroya, Álvaro, Ocaña, Angustias, Guzmán, María Fernanda, Pascual, M.J., Sánchez-Códez, María, Montesinos, Elena, Jensen, Julia, Rodríguez, María, Caro, Gloria, Gómez, Alba, Bretón, Rafael, Rodríguez, Margarita, Romero, Julio, Campos, Ana, García, Mercedes, Velasco, Rosa María, Lobato, Zulema, Rey, Corsino, Vivanco, Ana, Alcalá, Pedro, Solé, Eduard, Minguell, Laura, Astigarraga, Itziar, Vázquez, Ma Ángeles, Díaz, Elena, Consuegra, Eduardo, Cabanillas, María, Peña, Luis, Garrote, Elisa, Goicoechea, Maite, Centelles, Irene, Gutiérrez, Sara, Cavalle, Amparo, Olmos, José María, Cobo, Alejandro, Díaz, Sara, Jiménez, Beatriz, Lafuente, Miguel, Pons, Natividad, Morata, Julia, Segura, Elsa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: Adolescent; antigen test; Antigens, Viral - analysis; Brief Reports; Child; Child, Preschool; COVID-19; COVID-19 - diagnosis; COVID-19 - virology; DNA, Viral - analysis; Female; Humans; Infant; Infant, Newborn; Male; Nasopharynx - virology; Pandemics; PCR; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction - methods; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; COVID-19; NPS; CT; SARS-CoV-2; NLR; Ag; RT-PCR; PLR; antigen test; PCR
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2021.01.027

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019–compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.