Growth and development of children conceived by in-vitro maturation of human oocytes

• Published in: Early human development Vol. 82; no. 10; pp. 677 - 682
• Main Authors: MU, Shu-Chi, HWANG, Jiann-Loung, LIN, Yu-Hung, SUNG, Tseng-Chen, LIN, Ming-I, YEH, Tsu-Fuh
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier Ireland Ltd 01.10.2006; New York,NY Elsevier; Amsterdam
• Subjects: Bayley Scales; Biological and medical sciences; Body Height; Body Weight; Child; Child Development - physiology; Embryology: invertebrates and vertebrates. Teratology; Female; Fertilization in Vitro - methods; Follicle stimulation hormone (FSH) priming; Fundamental and applied biological sciences. Psychology; Human chorionic hormone (hCG) priming; Humans; In Vitro Techniques; In-vitro maturation (IVM); Infant; Intelligence Tests; Male; Mental Development Index (MDI) scores; Oocytes - growth & development; Psychomotor Development Index (PDI) scores; Mental Development Index (MDI) scores; In-vitro maturation (IVM); Human chorionic hormone (hCG) priming; Psychomotor Development Index (PDI) scores; Bayley Scales; Follicle stimulation hormone (FSH) priming; Human; Psychomotor development; Growth; Gonadotropin; In vitro; Placental hormone; Human chorionic gonadotrophin; Adenohypophyseal hormone; Child; Follicle stimulating hormone; Oocyte maturation
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2006.01.012

The objective of this study is to evaluate the physical and mental development of infants born on in-vitro maturation (IVM) programs. We compare 21 IVM children as study group and 21 non-IVM children as control group. We performed a general physical examination for malformations, neurological examination, developmental examination (Bayley Scales) on the IVM group and the non-IVM group. We found all the children with normal karyotype and without major malformation in both IVM and non-IVM groups. The mean Mental Development Index scores for IVM subjects and the comparison group were 92.71 ± 10.47 and 97.19 ± 8.88, respectively ( p = 0.074). The mean Psychomotor Development Index scores were 96.67 ± 8.91 and 96.19 ± 7.05, respectively ( p = 0.817). This is the first study designed to evaluate the physical growth and developmental indices of IVM children with combinational priming protocol of FSH and hCG. Our results suggest that IVM children didn’t show developmental delay during infancy and early childhood.