Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental Platforms

Recent developments in the study of epithelial ovarian cancer have called into question the traditional views regarding the site of tumor initiation. Histopathologic studies and genomic analyses suggest that extra-ovarian sites, like the fallopian tube, may harbor the coveted cell of origin and coul...

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Published inFrontiers in oncology Vol. 3; p. 217
Main Authors Jones, Paul Michael, Drapkin, Ronny
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2013
Subjects
fallopian tube
Genetics
model systems
Oncology
OSE
ovarian cancer
Pathogenesis
OSE
pathogenesis
genetics
model systems
fallopian tube
ovarian cancer
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Summary:Recent developments in the study of epithelial ovarian cancer have called into question the traditional views regarding the site of tumor initiation. Histopathologic studies and genomic analyses suggest that extra-ovarian sites, like the fallopian tube, may harbor the coveted cell of origin and could therefore contribute significantly to the development of high-grade serous ovarian carcinoma (HG-SOC). Our ability to validate these emerging genomic and pathologic observations and characterize the early transformation events of HG-SOC hinges on the development of novel model systems. Currently, there are only a handful of new model systems that are addressing these concerns. This review will chronicle the convergent evolution of these ovarian cancer model systems in the context of the changing pathologic and genomic understanding of HG-SOC.
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Reviewed by: Hannah Yang, National Cancer Institute, USA; Amir Jazaeri, University of Virginia, USA
This article was submitted to Women’s Cancer, a section of the journal Frontiers in Oncology.
Edited by: Viive Maarika Howell, University of Sydney, Australia
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2013.00217