Comparison of Nanocomposite Film and Electrospun Nanocomposite Fibers Based on Poly (2-Hydroxy Ethyl Methacrylate) and Microcrystalline Cellulose as Anticancer Implants

• Published in: Polymer-plastics technology and engineering Vol. 53; no. 16; pp. 1690 - 1696
• Main Authors: Srinivasa Rao, Sowmya, Rajiv, Sheeja
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 20.11.2014; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Applied sciences; Biocompatibility; Biological and medical sciences; Biotechnology; Cellulose; Cellulose fibers; Composites; Crystalline cellulose; Drug delivery; Electrospinning; Encapsulation; Exact sciences and technology; Fibers; Fibers and threads; Forms of application and semi-finished materials; Medical sciences; Microcrystalline cellulose; Nanocomposites; Nanostructure; p(HEMA); Paclitaxel; Polymer industry, paints, wood; Scaffolds; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology of polymers; Technology. Biomaterials. Equipments; X-ray diffraction; Antineoplastic agent; Biological properties; Microcrystalline material; Implant; Film; Control release polymer; Cellulose; Synthetic fiber; Electrospinning; Drug carrier; Drug delivery; Experimental study; In vitro; Composite material; Hydroxyethyl methacrylate polymer; Solvent spinning; p(HEMA); Microcrystalline cellulose; Preparation; Paclitaxel; Biocompatibility; Biomaterial; Nanocomposite; Release
• ISSN: 0360-2559; 1525-6111
• DOI: 10.1080/03602559.2014.919654

In the present study nanocomposite fibers and film scaffolds based on poly (2-hydroxy ethyl methacrylate) and microcrystalline cellulose were prepared by electrospinning method and solvent casting method, respectively. Paclitaxel (20 ppm) was incorporated during the preparation of fibers and film to result in paclitaxel-incorporated nanocomposite film and fibers with an encapsulation efficiency of 63% and 72%, respectively. These prepared nanocomposite films and fibers were characterized and confirmed by FTIR, XRD and SEM analysis. The biocompatibility of the nanocomposite scaffolds were assessed using VERO cell lines. The in vitro release of paclitaxel from the nanocomposite fibers, and film was found to be 74 ± 1.2% and 64 ± 1.2%, respectively.