Nonsense Suppression Therapy: An Emerging Treatment for Hereditary Skin Diseases

Nonsense mutations cause the premature termination of protein translation via premature termination codons (PTCs), leading to the synthesis of incomplete functional proteins and causing large numbers of genetic disorders. The emergence of nonsense suppression therapy is considered to be an effective...

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Bibliographic Details
Published inActa dermato-venereologica Vol. 102; p. adv00658
Main Authors Yu, Jiangfan, Tang, Bingsi, He, Xinglan, Zou, Puyu, Zeng, Zhuotong, Xiao, Rong
Format Journal Article
LanguageEnglish
Published Sweden Society for Publication of Acta Dermato-Venereologica 28.02.2022
Medical Journals Sweden
Subjects
aminoglycosides
Codon, Nonsense
hereditary skin diseases
Humans
nonsense-mediated decay
Protein Biosynthesis
PTC124
readthrough
Review
Skin Diseases - drug therapy
Skin Diseases - genetics
suppressor tRNA
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Summary:Nonsense mutations cause the premature termination of protein translation via premature termination codons (PTCs), leading to the synthesis of incomplete functional proteins and causing large numbers of genetic disorders. The emergence of nonsense suppression therapy is considered to be an effective method for the treatment of hereditary diseases, but its application in hereditary skin diseases is relatively limited. This review summarizes the current research status of nonsense suppression therapy for hereditary skin diseases, and discusses the potential opportunities and challenges of applying new technologies related to nonsense suppression therapy to dermatology. Further research is needed into the possible use of nonsense suppression therapy as a strategy for the safer and specific treatment of hereditary skin diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0001-5555
1651-2057
DOI:10.2340/actadv.v102.353