Rubella Virus Is Associated With Fuchs Heterochromic Iridocyclitis

To determine whether rubella virus (RV) is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI). Retrospective patient-controlled study. Intraocular immunoglobulin G production against RV, herpes simplex virus (HSV), varicella zoster virus (VZV), and Toxoplasma gondii was determin...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of ophthalmology Vol. 141; no. 1; pp. 212 - 214.e1
Main Authors de Groot-Mijnes, Jolanda D.F., de Visser, Lenneke, Rothova, Aniki, Schuller, Margje, van Loon, Anton M., Weersink, Annemarie J.L.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 2006
Elsevier
Elsevier Limited
Subjects
Adult
Aged
Antibodies, Viral - analysis
Aqueous Humor - virology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Enzymes
Eye Infections, Viral - virology
Female
Humans
Humor
Immune system
Immunoglobulin G - analysis
Iridocyclitis - virology
Laboratories
Male
Medical sciences
Middle Aged
Miscellaneous
Ophthalmology
Patients
Retrospective Studies
Rubella - virology
Rubella virus - immunology
Rubella virus - isolation & purification
Uvea diseases
Virus
Associated virus
Eye disease
Iridocyclitis
Rubivirus
Togaviridae
Uvea disease
Ophthalmology
Rubella virus
Anterior segment disease
Online AccessGet full text
ISSN0002-9394
1879-1891
DOI10.1016/j.ajo.2005.07.078

Cover

More Information
Summary:To determine whether rubella virus (RV) is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI). Retrospective patient-controlled study. Intraocular immunoglobulin G production against RV, herpes simplex virus (HSV), varicella zoster virus (VZV), and Toxoplasma gondii was determined in the aqueous humor of 14 patients with FHI, 13 control subjects with herpetic uveitis anterior, and 19 control subjects with ocular toxoplasmosis by calculation of the Goldmann-Witmer coefficient (GWC). All patients and control subjects were seropositive for RV. Intraocular antibody production (GWC >3) against RV was found in 13 of 14 patients (93%) with FHI. Intraocular antibody production against HSV, VZV, or T gondii was not detected. None of the control subjects with herpetic uveitis anterior or with toxoplasma chorioretinitis had a positive GWC for rubella virus ( P < .0001, Fisher exact test). Rubella virus, but not HSV, VZV, or T gondii, is associated with FHI.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2005.07.078