Association of intercellular adhesion molecule-1 gene polymorphism with coronary heart disease

• Published in: Molecular medicine reports Vol. 10; no. 3; pp. 1343 - 1348
• Main Authors: LUO, JUN-YI, MA, YI-TONG, XIE, XIANG, YANG, YI-NING, LI, XIAO-MEI, MA, XIANG, YU, ZIXIANG, CHEN, BANG-DANG, LIU, FEN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.09.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Aged; Alcohol; Alleles; Analysis; Arteriosclerosis; Asian Continental Ancestry Group - genetics; Atherosclerosis; Cardiovascular disease; Case-Control Studies; Cell activation; Cell adhesion; Cell adhesion molecules; Cholesterol; Coronary artery disease; Coronary Disease - genetics; Coronary heart disease; Deoxyribonucleic acid; DNA; Family medical history; Female; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotype; Genotype & phenotype; Genotyping Techniques; Han; Health risk assessment; Heart; Heart diseases; Hospitals; Humans; Hypertension; Identification and classification; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Laboratories; Leukocyte migration; Life Style; Logistic Models; Low density lipoprotein; Male; Males; Middle Aged; Polymerase Chain Reaction; polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Restriction fragment length polymorphism; Risk Factors; Standard deviation; Studies; China
• ISSN: 1791-2997; 1791-3004; 1791-3004
• DOI: 10.3892/mmr.2014.2360

Intercellular adhesion molecule-1 (ICAM-1) is an important adhesion molecule that has a crucial role in lymphocyte migration and atherosclerosis pathogenesis activation. The aim of the present study was to explore the association between the rs5498 polymorphism of the ICAM-1 gene and coronary heart disease (CHD). The rs5498 polymorphism of the ICAM-1 gene was detected using polymerase chain reaction-restriction fragment length polymorphism in 674 patients with CHD and 779 control subjects. The results showed that the frequency of the G allele was significantly higher in patients with CHD than that in controls (29.1 vs. 23.3%; P<0.001). The frequency of the AG+GG genotypes was higher in patients with CHD than that in controls (49.7 vs. 40.8%; P=0.001). Multiple logistic regression analysis showed that AG+GG was an independent risk factor for CHD (odds ratio, 1.919; 95% confidence intervals, 1.471-2.503; P<0.001). For males, the frequencies of the G allele and AG+GG genotype were also higher in patients with CHD than those in control subjects (frequency of G allele, 29.9 vs. 22.7%; P<0.001; frequency of AG+GG genotype, 50.6 vs. 40.3%; P=0.001). For females, no significant differences in genotype or allele distribution were observed between the two groups. In conclusion, it was demonstrated in the present study that the rs5498 polymorphism of the ICAM-1 gene was associated with CHD in males. Males with the G allele (AG and GG genotype) may therefore have a higher risk for CHD than those with the AA genotype.