The molecular organization of cerebellar long-term depression

Synaptic plasticity is an important cellular mechanism for the formation of memory in neuronal circuits of the brain. Research during the past two decades has revealed surprisingly complex signal-transduction processes that underlie various forms of synaptic plasticity. More than 30 molecules are in...

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Bibliographic Details
Published inNature reviews. Neuroscience Vol. 3; no. 11; pp. 896 - 902
Main Author Ito, Masao
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.11.2002
Subjects
Animals
Brain research
Cerebellum - cytology
Cerebellum - physiology
Humans
Kinases
Long-Term Synaptic Depression - physiology
Neural Pathways - cytology
Neural Pathways - physiology
Neurotransmitter Agents - metabolism
Presynaptic Terminals - physiology
Proteins
Receptors, Neurotransmitter - metabolism
Second Messenger Systems - physiology
Signal transduction
Signal Transduction - physiology
Synaptic Transmission - physiology
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Summary:Synaptic plasticity is an important cellular mechanism for the formation of memory in neuronal circuits of the brain. Research during the past two decades has revealed surprisingly complex signal-transduction processes that underlie various forms of synaptic plasticity. More than 30 molecules are involved in the induction of long-term depression (LTD) -- a unique form of synaptic plasticity in the cerebellum. Here, I review recent data on these molecules, defining their roles as mediators or modulators, coincidence detectors or components of a self-regenerating circuit, and show how they are organized to form an efficient molecular machinery for LTD induction.
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ISSN:1471-003X
1471-0048
1471-0048
1469-3178
DOI:10.1038/nrn962