Multiplex Partial Nephrectomy, Repeat Partial Nephrectomy, and Salvage Partial Nephrectomy Remain the Primary Treatment in Multifocal and Hereditary Kidney Cancer

• Published in: Frontiers in oncology Vol. 7; p. 244
• Main Authors: Baiocco, Joseph A, Metwalli, Adam R
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.10.2017
• Subjects: hereditary kidney cancer; multifocal kidney cancer; multiplex partial nephrectomy; Oncology; renal transplant; repeat partial nephrectomy; salvage partial nephrectomy; hereditary cancer syndromes; renal transplant; multifocal kidney cancer; multiplex partial nephrectomy; repeat partial nephrectomy; salvage partial nephrectomy; hereditary kidney cancer
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2017.00244

The standard of care treatment for solitary renal cell carcinoma (RCC) tumors 4 cm or less is partial nephrectomy (PNx). However, multifocal kidney cancer presents unique challenges for treating physicians. Historically, total nephrectomy and hemodialysis with possible renal transplant later was the primary therapeutic strategy for these patients. Later, as nephron sparing surgical approaches improved, PNx became the standard of care for patients presenting with multifocal and hereditary RCC. Surgeries to remove multiple renal tumors simultaneously produce different perioperative outcomes and increased risk of complications. Due to these differences in technique and outcomes, the term multiplex partial nephrectomy (MxPNx) has been coined to designate these differences. Here, we discuss the role that MxPNx continues to play in multifocal RCC.