The LDL1/2-HDA6 Histone Modification Complex Interacts With TOC1 and Regulates the Core Circadian Clock Components in Arabidopsis

In , the circadian rhythm is associated with multiple important biological processes and maintained by multiple interconnected loops that generate robust rhythms. The circadian clock central loop is a negative feedback loop composed of the core circadian clock components. ( ) is highly expressed in...

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Published inFrontiers in plant science Vol. 10; p. 233
Main Authors Hung, Fu-Yu, Chen, Fang-Fang, Li, Chenlong, Chen, Chen, Chen, Jian-Hao, Cui, Yuhai, Wu, Keqiang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.02.2019
Subjects
Arabidopsis
CCA1/LHY
circadian clock
H3K4 demethylases
HDA6
Plant Science
TOC1
HDA6
CCA1/LHY
Arabidopsis
circadian clock
H3K4 demethylases
TOC1
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Summary:In , the circadian rhythm is associated with multiple important biological processes and maintained by multiple interconnected loops that generate robust rhythms. The circadian clock central loop is a negative feedback loop composed of the core circadian clock components. ( ) is highly expressed in the evening and negatively regulates the expression of ( )/ ( ). CCA1/LHY also binds to the promoter of and represses the expression. Our recent research revealed that the histone modification complex comprising of LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1)-LIKE 1/2 (LDL1/2) and HISTONE DEACETYLASE 6 (HDA6) can be recruited by CCA1/LHY to repress expression. In this study, we found that HDA6, LDL1, and LDL2 can interact with TOC1, and the LDL1/2-HDA6 complex is associate with TOC1 to repress the expression. Furthermore, LDL1/2-HDA6 and TOC1 co-target a subset of genes involved in the circadian rhythm. Collectively, our results indicate that the LDL1/2-HDA6 histone modification complex is important for the regulation of the core circadian clock components.
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Reviewed by: R. Glen Uhrig, University of Alberta, Canada; Jun Xiao, Institute of Genetics and Developmental Biology (CAS), China
Edited by: Jean-Benoit Charron, McGill University, Canada
This article was submitted to Plant Cell Biology, a section of the journal Frontiers in Plant Science
ISSN:1664-462X
1664-462X
DOI:10.3389/fpls.2019.00233