Direct effect of protein kinase C inhibitors on cardiovascular ion channels

• Published in: BMB reports Vol. 44; no. 9; pp. 559 - 565
• Main Authors: Son, Y.K., Kangwon National University School of Medicine, Chuncheon, Republic of Korea, Hong, D.H., Kangwon National University School of Medicine, Chuncheon, Republic of Korea, Kim, D.J., Kangwon National University School of Medicine, Chuncheon, Republic of Korea, Firth, Amy L, The Salk Institute of Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, USA, Park, W.S., Kangwon National University School of Medicine, Chuncheon, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) 생화학분자생물학회 01.09.2011
• Subjects: Bisindolylmaleimide (I); Chelerythrine; Humans; Indoles - chemistry; Indoles - pharmacology; Ion channel; Ion Channels - drug effects; Ion Channels - metabolism; Maleimides - chemistry; Maleimides - pharmacology; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - enzymology; Muscle, Smooth, Vascular - metabolism; PROTEIN KINASE; Protein kinase C; Protein Kinase C - antagonists & inhibitors; Protein Kinase C - metabolism; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; PROTEINA QUINASA; PROTEINE KINASE; Ro 31-8220; Rottlerin; Staurosporine; Staurosporine - chemistry; Staurosporine - pharmacology; 화학
• ISSN: 1976-6696; 1976-670X
• DOI: 10.5483/BMBRep.2011.44.9.559

Protein kinase C (PKC) is a central enzyme that modulates numerous biological functions. For this reason, specific PKC inhibitors/activators are required to study PKC-related signaling mechanisms. To date, although many PKC inhibitors have been developed, they are limited by poor selectivity and nonspecificity. In this review, we focus on the nonspecific actions of PKC inhibitors on cardiovascular ion channels in addition to their PKC-inhibiting functions. The aim of this paper is to urge caution when using PKC inhibitors to block PKC function. This information may help to better understand PKC-related physiological/biochemical studies.