Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese
The recently discovered apolipoprotein A5 ( APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and −1131T>C with coronary heart disease (CHD) i...
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Published in | Metabolism, clinical and experimental Vol. 54; no. 5; pp. 568 - 572 |
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Main Authors | , , , , , , , , , , , , , , |
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Language | English |
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01.05.2005
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Abstract | The recently discovered apolipoprotein A5 (
APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the
APOA5 gene polymorphisms S19W and −1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction–restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively (
P < .000001), and the minor allele −1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299,
P < .0001). These results suggest that both the S19W and −1131T>C variations in the
APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in −1131C carriers than in −1131T subjects of the control group and that high-density–lipoprotein cholesterol was decreased in −1131C carriers among CHD patients. |
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AbstractList | The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and -1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively ( P < .000001), and the minor allele -1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299, P < .0001). These results suggest that both the S19W and -1131T>C variations in the APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in -1131C carriers than in -1131T subjects of the control group and that high-density-lipoprotein cholesterol was decreased in -1131C carriers among CHD patients. The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and -1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively ( P < .000001), and the minor allele -1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299, P < .0001). These results suggest that both the S19W and -1131T>C variations in the APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in -1131C carriers than in -1131T subjects of the control group and that high-density-lipoprotein cholesterol was decreased in -1131C carriers among CHD patients. The recently discovered apolipoprotein A5 ( APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and −1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction–restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively ( P < .000001), and the minor allele −1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299, P < .0001). These results suggest that both the S19W and −1131T>C variations in the APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in −1131C carriers than in −1131T subjects of the control group and that high-density–lipoprotein cholesterol was decreased in −1131C carriers among CHD patients. |
Author | Liu, Hekun Huang, Aimin Lin, Jianyin Su, Zhiguang Huang, Dejia Zheng, Keqin Shi, Jiajun Wang, Chunting Zhang, Sizhong Nebert, Daniel W. Xiao, Cuiying Li, Xuefei Li, Guixin Zhou, Bing Li, Hai |
Author_xml | – sequence: 1 givenname: Hekun surname: Liu fullname: Liu, Hekun organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 2 givenname: Sizhong surname: Zhang fullname: Zhang, Sizhong email: szzhang@mcwcums.com organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 3 givenname: Jianyin surname: Lin fullname: Lin, Jianyin organization: Department of Cell Biology and Genetics, Fujian Medical University, Fuzhou 350004, China – sequence: 4 givenname: Hai surname: Li fullname: Li, Hai organization: Department of Advanced Mathematics, College of Mathematics, Sichuan University, Chengdu 610041, China – sequence: 5 givenname: Aimin surname: Huang fullname: Huang, Aimin organization: Department of Cell Biology and Genetics, Fujian Medical University, Fuzhou 350004, China – sequence: 6 givenname: Cuiying surname: Xiao fullname: Xiao, Cuiying organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 7 givenname: Xuefei surname: Li fullname: Li, Xuefei organization: Department of Cell Biology and Genetics, Fujian Medical University, Fuzhou 350004, China – sequence: 8 givenname: Zhiguang surname: Su fullname: Su, Zhiguang organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 9 givenname: Chunting surname: Wang fullname: Wang, Chunting organization: Department of Cell Biology and Genetics, Fujian Medical University, Fuzhou 350004, China – sequence: 10 givenname: Daniel W. surname: Nebert fullname: Nebert, Daniel W. organization: Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0056, USA – sequence: 11 givenname: Bing surname: Zhou fullname: Zhou, Bing organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 12 givenname: Keqin surname: Zheng fullname: Zheng, Keqin organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 13 givenname: Jiajun surname: Shi fullname: Shi, Jiajun organization: State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 14 givenname: Guixin surname: Li fullname: Li, Guixin organization: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 15 givenname: Dejia surname: Huang fullname: Huang, Dejia organization: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China |
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Keywords | Triglycerides Single nucleotide polymorphisms Apolipoprotein A5 Chinese population study Coronary heart disease Human Site Lipids Cardiovascular disease Patient Apolipoprotein Triglyceride Frequency control Blood plasma Vascular disease Polymerase chain reaction Variant Association Restriction fragment length polymorphism Gene DNA Atherosclerosis Risk factor Total Chinese Population Level |
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Snippet | The recently discovered apolipoprotein A5 (
APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular... The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular... |
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SubjectTerms | Apolipoprotein A-V Apolipoprotein A5 Apolipoproteins - genetics Apolipoproteins A Asian Continental Ancestry Group - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Chinese population study Cholesterol, HDL - blood Coronary Disease - blood Coronary Disease - genetics Coronary heart disease Cytosine DNA - genetics Fasting - blood Female Genetic Variation Heart Heterozygote Humans Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Serine Single nucleotide polymorphisms Thymine Triglycerides Triglycerides - blood Tryptophan |
Title | Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese |
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