Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese
The recently discovered apolipoprotein A5 ( APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and −1131T>C with coronary heart disease (CHD) i...
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Published in | Metabolism, clinical and experimental Vol. 54; no. 5; pp. 568 - 572 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.2005
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The recently discovered apolipoprotein A5 (
APOA5) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the
APOA5 gene polymorphisms S19W and −1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction–restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively (
P < .000001), and the minor allele −1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299,
P < .0001). These results suggest that both the S19W and −1131T>C variations in the
APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in −1131C carriers than in −1131T subjects of the control group and that high-density–lipoprotein cholesterol was decreased in −1131C carriers among CHD patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0026-0495 1532-8600 |
DOI: | 10.1016/j.metabol.2004.11.009 |