nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction

Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED). Patients (n = 137) were divided as clinical ED or postoperative...

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Published inPharmacogenomics Vol. 15; no. 6; pp. 775 - 784
Main Authors Lacchini, Riccardo, Muniz, Jaqueline J, Nobre, Yuri TDA, Cologna, Adauto J, Martins, Antonio CP, Tanus-Santos, Jose E
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.04.2014
Subjects
Analysis
Care and treatment
Diabetes
Disease
Drug dosages
Enzymes
Erectile dysfunction
Erectile Dysfunction - drug therapy
Erectile Dysfunction - genetics
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Haplotypes
Health aspects
Humans
Hypertension
Impotence
Male
Middle Aged
Nitric oxide
Nitric Oxide Synthase Type I - genetics
Nitric-oxide synthase
Penis
Piperazines - therapeutic use
Polymorphism, Genetic - genetics
polymorphisms
Postoperative Period
Prostatectomy
Purines - therapeutic use
Signal transduction
Sildenafil
Sildenafil Citrate
Smooth muscle
Statistical analysis
Sulfones - therapeutic use
Thermal cycling
Trauma
Urological surgery
Brazil
prostatectomy
nitric oxide
NOS1
polymorphisms
sildenafil
erectile dysfunction
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Summary:Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED). Patients (n = 137) were divided as clinical ED or postoperative ED. They were subdivided as good responders or poor responders to sildenafil, and genotypes for rs41279104 and rs2682826 polymorphisms were determined. We found that the rs41279104 CT genotype was associated with good responders in postoperative ED patients, while rs2682826 CT genotype was associated with good responders in postoperative ED, and the TT genotype associated with good responders in both groups. Finally, the CT haplotype was associated with good responders in postoperative ED. polymorphisms are associated with responsiveness to sildenafil in ED. Original submitted 20 November 2013; Revision submitted 31 January 2014
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ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.14.30