Evaluation of cognitive impairment in a French sample of patients with restrictive anorexia nervosa: two distinct profiles emerged with differences in impaired functions and psychopathological symptoms

• Published in: Eating and weight disorders Vol. 26; no. 5; pp. 1559 - 1570
• Main Authors: Cholet, J., Rousselet, M., Donnio, Y., Burlot, M., Pere, M., Lambert, S., Rocher, B., Chirio-Espitalier, M., Eyzop, E., Grall-Bronnec, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2021; Springer Nature B.V; Springer Verlag
• Subjects: Anorexia; Anorexia Nervosa; Cognition; Cognitive ability; Cognitive Dysfunction; Cognitive Sciences; Emotions; Feeding and Eating Disorders; Female; Food and Nutrition; Humans; Impulsivity; Information processing; Life Sciences; Medicine; Medicine & Public Health; Neurons and Cognition; Neuropsychological Tests; NTC; NTC02381639; Original; Original Article; Processing speed; Psychiatry; Psychopathology; Santé publique et épidémiologie; Executive functions; Cognition; Cognitive flexibility; Anorexia nervosa; Intelligence quotient
• ISSN: 1590-1262; 1124-4909; 1590-1262
• DOI: 10.1007/s40519-020-00981-w

Purpose The cognitive profiles of patients suffering from anorexia nervosa (AN) are currently explored as potential facilitating and/or maintenance factors. Specific data in restrictive AN (AN-R) remain contradictory. This study focused on women with AN-R to evaluate their cognitive functions to develop a more specific cognitive remediation program. Methods Female patients older than 15 years who were suffering from AN-R were recruited in a specialized unit for eating disorder management. Female healthy control (HC) participants were recruited who were matched with AN patients on age. All participants completed a cognitive evaluation (premorbid intelligence quotient (IQ), planning, information processing speed, cognitive flexibility) and a clinical evaluation (impulsivity, anxiety, depression). Results A total of 122 participants were included. Patients suffering from AN-R had significant impairment in information processing speed and planning. Patients exhibited significantly better cognitive flexibility than did the HC group when adjustments were made for other cognitive functions and impulsivity. Two distinct subgroups of patients were identified. The first subgroup had more marked cognitive impairment and fewer psychopathological symptoms than did the second subgroup of patients and the HC group. Conclusion Our results highlight cognitive impairment in patients with AN who had normal premorbid IQ. Two distinct profiles emerge. In clinical practice, these results open up perspectives for the development of more specific cognitive remediation programs (one specific program for cold cognitions and another specific program targeting emotions and hot cognitions). These results warrant confirmation by larger studies with a more specific evaluation of the impact of emotional status. Trial registration NTC02381639, Date of registration. March 6, 2015