Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants

• Published in: The Journal of pediatrics Vol. 175; pp. 100 - 105.e2
• Main Authors: Colaizy, Tarah T., MD, MPH, Bartick, Melissa C., MD, MSc, Jegier, Briana J., PhD, Green, Brittany D., MSc, Reinhold, Arnold G., MBA, Schaefer, Andrew J., PhD, Bogen, Debra L., MD, Schwarz, Eleanor Bimla, MD, MS, Stuebe, Alison M., MD, MSc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016
• Subjects: Breast Feeding - economics; economic analysis; Enterocolitis, Necrotizing - economics; Enterocolitis, Necrotizing - epidemiology; Enterocolitis, Necrotizing - prevention & control; Health Care Costs - statistics & numerical data; human milk; Humans; Infant Formula - economics; Infant, Extremely Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - economics; Infant, Premature, Diseases - epidemiology; Infant, Premature, Diseases - prevention & control; Milk, Human; Models, Economic; Monte Carlo Method; monte carlo modeling; necrotizing enterocolitis; Pediatrics; United States - epidemiology; Extremely low birth weight; VLBW; Vermont Oxford Network; economic analysis; PMA; Very low birth weight; monte carlo modeling; NICU; Preterm formula; human milk; NEC; necrotizing enterocolitis; Postmenstrual age; VON; Neonatal intensive care unit; PF; ELBW
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2016.03.040

Objective To estimate risk of necrotizing enterocolitis (NEC) for extremely low birth weight (ELBW) infants as a function of preterm formula (PF) and maternal milk intake and calculate the impact of suboptimal feeding on the incidence and costs of NEC. Study design We used aORs derived from the Glutamine Trial to perform Monte Carlo simulation of a cohort of ELBW infants under current suboptimal feeding practices, compared with a theoretical cohort in which 90% of infants received at least 98% human milk. Results NEC incidence among infants receiving ≥98% human milk was 1.3%; 11.1% among infants fed only PF; and 8.2% among infants fed a mixed diet ( P  = .002). In adjusted models, compared with infants fed predominantly human milk, we found an increased risk of NEC associated with exclusive PF (aOR = 12.1, 95% CI 1.5, 94.2), or a mixed diet (aOR 8.7, 95% CI 1.2-65.2). In Monte Carlo simulation, current feeding of ELBW infants was associated with 928 excess NEC cases and 121 excess deaths annually, compared with a model in which 90% of infants received ≥98% human milk. These models estimated an annual cost of suboptimal feeding of ELBW infants of $27.1 million (CI $24 million, $30.4 million) in direct medical costs, $563 655 (CI $476 191, $599 069) in indirect nonmedical costs, and $1.5 billion (CI $1.3 billion, $1.6 billion) in cost attributable to premature death. Conclusions Among ELBW infants, not being fed predominantly human milk is associated with an increased risk of NEC. Efforts to support milk production by mothers of ELBW infants may prevent infant deaths and reduce costs.