MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery

• Published in: Respiratory research Vol. 25; no. 1; p. 117
• Main Authors: van Paassen, Judith, Hiemstra, Pieter S, van der Linden, Abraham C, de Jonge, Evert, Zwaginga, Jaap Jan, Klautz, Robert J M, Arbous, M Sesmu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.03.2024; BioMed Central; BMC
• Subjects: Acute Lung Injury - diagnosis; Acute Lung Injury - etiology; Acute respiratory distress syndrome; Adult; Adult respiratory distress syndrome; Airway management; Analysis; ARDS; Biomarkers; Biomarkers - analysis; Bronchoalveolar Lavage Fluid; Bronchus; Cardiac surgery; Cardiac Surgical Procedures - adverse effects; Care and treatment; Chronic obstructive pulmonary disease; Clinical outcomes; Diagnosis; Elastase; Heart; Heart surgery; Humans; Injuries; Intensive care; Lavage; Leukocytes (neutrophilic); Lung diseases; Lungs; Mortality; Mucin; Mucin 5AC - metabolism; Mucins; Neutrophils; Pathogenesis; Pathogens; Patients; Perioperative care; Prospective Studies; Pulmonary biomarkers; Respiratory distress syndrome; Risk factors; Surgery; Netherlands; Pulmonary biomarkers; Intensive care; Perioperative care; Cardiac surgery; ARDS; Mucins
• ISSN: 1465-993X; 1465-9921; 1465-993X; 1465-9921
• DOI: 10.1186/s12931-024-02747-9

Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pre- and post-surgery non-fiberscopic miniBAL fluids were analysed for MUC5AC, MUC5B, IL-8, human neutrophil elastase, and neutrophils. All measured biomarkers increased after surgery. Perioperative MUC5AC-change showed a significant negative association with postoperative P/F ratio (p = 0.018), and a positive association with ICU stay (p = 0.027). In conclusion, development of lung injury after cardiac surgery and prolonged ICU stay are associated with an early increase of MUC5AC as detected in mini-BAL.