Epitranscriptomic RNA Methylation in Plant Development and Abiotic Stress Responses

Recent advances in methylated RNA immunoprecipitation followed by sequencing and mass spectrometry have revealed widespread chemical modifications on mRNAs. Methylation of RNA bases such as -methyladenosine (m A) and 5-methylcytidine (m C) is the most prevalent mRNA modifications found in eukaryotes...

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Published inFrontiers in plant science Vol. 10; p. 500
Main Authors Hu, Jianzhong, Manduzio, Stefano, Kang, Hunseung
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.04.2019
Subjects
abiotic stress
epitranscriptome
Plant Science
RNA metabolism
RNA methylation
RNA modification
RNA modification
epitranscriptome
RNA methylation
RNA metabolism
abiotic stress
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Summary:Recent advances in methylated RNA immunoprecipitation followed by sequencing and mass spectrometry have revealed widespread chemical modifications on mRNAs. Methylation of RNA bases such as -methyladenosine (m A) and 5-methylcytidine (m C) is the most prevalent mRNA modifications found in eukaryotes. In recent years, cellular factors introducing, interpreting, and deleting specific methylation marks on mRNAs, designated as "writers (methyltransferase)," "readers (RNA-binding protein)," and "erasers (demethylase)," respectively, have been identified in plants and animals. An emerging body of evidence shows that methylation on mRNAs affects diverse aspects of RNA metabolism, including stability, splicing, nucleus-to-cytoplasm export, alternative polyadenylation, and translation. Although our understanding for roles of writers, readers, and erasers in plants is far behind that for their animal counterparts, accumulating reports clearly demonstrate that these factors are essential for plant growth and abiotic stress responses. This review emphasizes the crucial roles of epitranscriptomic modifications of RNAs in new layer of gene expression regulation during the growth and response of plants to abiotic stresses.
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Reviewed by: Andreas Bachmair, University of Vienna, Austria; Byungho-Ho Kang, The Chinese University of Hong Kong, China
These authors have contributed equally to this work
Edited by: Sang Yeol Lee, Gyeongsang National University, South Korea
This article was submitted to Plant Abiotic Stress, a section of the journal Frontiers in Plant Science
ISSN:1664-462X
1664-462X
DOI:10.3389/fpls.2019.00500