Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases

• Published in: Biochimica et biophysica acta. Reviews on cancer Vol. 1873; no. 1; p. 188316
• Main Authors: Gupta, Subash C., Awasthee, Nikee, Rai, Vipin, Chava, Srinivas, Gunda, Venugopal, Challagundla, Kishore B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2020
• Subjects: Animals; Cancer; Chronic disease; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease - genetics; Humans; LncRNA; MicroRNAs - genetics; Neoplasms - genetics; Neoplasms - pathology; NF-kappa B - genetics; NF-κB; Non-coding RNA; RNA, Long Noncoding - genetics; Signal Transduction - genetics; HOTAIR; CAMK2D; LncRNA; C2dat1; PHB2; LPS; Arid2; NKILA; ANRIL; MTX; NF-κB; TNM; OGD/R; miRNA; PACER; Mirt1; OSCC; IL; NSCLC; Chronic disease; VEGF; Carlr; HCC; EMT; RA; TNF-α; ROS; TSCC; MALAT1; Sirt1; Non-coding RNA; MIR31HG; Cancer; NOX2
• ISSN: 0304-419X; 1879-2561
• DOI: 10.1016/j.bbcan.2019.188316

The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.