Germ Cells Regulate 3-Hydroxybutyrate Production In Rat Sertoli Cells

Highlights • Spermatocytes and spermatids increase 3-hydroxybutyrate production in Sertoli cells. • Germ cells regulate mRNA levels of CPT1a, mHMGCoA synthase and MCT4. • Germinal cell-conditioned medium and bFGF increase 3-hydroxybutyrate production.

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 248; pp. 5 - 15
Main Authors Mariana, Regueira, Gustavo Marcelo, Rindone, María Noel, Galardo, Eliana Herminia, Pellizzari, Selva Beatriz, Cigorraga, Silvina Beatriz, Meroni, María Fernanda, Riera
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2017
Subjects
3-Hydroxybutyric Acid - biosynthesis
Animals
Cells, Cultured
Coculture Techniques
CPT1a
Culture Media, Conditioned - pharmacology
Endocrinology & Metabolism
Fibroblast Growth Factor 2 - pharmacology
Gene Expression Regulation - drug effects
Germ cell
Germ Cells - drug effects
Germ Cells - metabolism
Insulin-Like Growth Factor I - pharmacology
Ketone bodies
Ketone Bodies - metabolism
Male
MCT4
mHMGCoA synthase
Rats, Sprague-Dawley
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sertoli cell
Sertoli Cells - drug effects
Sertoli Cells - metabolism
KETONE BODIES
SERTOLI CELL
CPT1a
MCT4
GERM CELL
mHMGCoA SYNTHASE
Germ cell
Sertoli cell
Ketone bodies
mHMGCoA synthase
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Summary:Highlights • Spermatocytes and spermatids increase 3-hydroxybutyrate production in Sertoli cells. • Germ cells regulate mRNA levels of CPT1a, mHMGCoA synthase and MCT4. • Germinal cell-conditioned medium and bFGF increase 3-hydroxybutyrate production.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2017.04.007