Prognostic and immunological value of LTB4R in pan-cancer

• Published in: Mathematical biosciences and engineering : MBE Vol. 18; no. 6; pp. 9336 - 9356
• Main Authors: Long, Sidan, Ji, Shuangshuang, Xiao, Kunmin, Xue, Peng, Zhu, Shijie
• Format: Journal Article
• Language: English
• Published: United States AIMS Press 01.01.2021
• Subjects: Biomarkers, Tumor; Carcinoma, Hepatocellular; Humans; immune infiltration; Kaplan-Meier Estimate; leukotriene b4 receptor 1; Liver Neoplasms; Lymphocytes, Tumor-Infiltrating; pan-cancer; Prognosis; Receptors, Leukotriene B4 - genetics; survival analysis; Tumor Microenvironment; leukotriene B4 receptor 1; database; pan-cancer; tumor microenvironment; immune infiltration; survival analysis
• ISSN: 1551-0018; 1551-0018
• DOI: 10.3934/mbe.2021459

LTB4 receptor 1 (LTB4R), as the high affinity leukotriene B4 receptor, is rapidly revealing its function in malignancies. However, it is still uncertain. We investigated the expression pattern and prognostic significance of LTB4R in pan-cancer across different databases, including ONCOMINE, PrognoScan, GEPIA, and Kaplan-Meier Plotter, in this study. Meanwhile, we explored the significance of LTB4R in tumor metastasis by HCMDB. Then functional enrichment analysis of related genes was performed using GeneMANIA and DAVID. Lastly, utilizing the TIMER datasets, we looked into the links between LTB4R expression and immune infiltration in malignancies. In general, tumor tissue displayed higher levels of LTB4R expression than normal tissue. Although LTB4R had a negative influence on pan-cancer, a high expression level of LTB4R was protective of LIHC (liver hepatocellular carcinoma) patients' survival. There was no significant difference in the distribution of LTB4R between non-metastatic and metastatic tumors. Based on Gene Set Enrichment Analysis, LTB4R was implicated in pathways involved in inflammation, immunity, metabolism, and cancer diseases. The correlation between immune cells and LTB4R was found to be distinct across cancer types. Furthermore, markers of infiltrating immune cells, such as Treg, T cell exhaustion and T helper cells, exhibited different LTB4R-related immune infiltration patterns. The LTB4R is associated with immune infiltrates and can be used as a prognostic biomarker in pan-cancer.