Telomeres and the nucleus

Abstract Telomeres are crucial for the maintenance of genome stability through “capping” of chromosome ends to prevent their recognition as double-strand breaks, thus avoiding end-to-end fusions or illegitimate recombination [1–3] . Similar to other genomic regions, telomeres participate to the nucl...

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Published inSeminars in cancer biology Vol. 23; no. 2; pp. 116 - 124
Main Authors Novo, Clara Lopes, Londoño-Vallejo, J. Arturo
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Animals
Cancer
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cell Nucleus - physiology
Cell Nucleus - ultrastructure
Chromatin Assembly and Disassembly - physiology
DNA Replication - genetics
DNA Replication - physiology
Genomic Instability - physiology
Hematology, Oncology and Palliative Medicine
Humans
Models, Biological
Neoplasms - genetics
Neoplasms - pathology
Nuclear organization
Telomere
Telomere - chemistry
Telomere - genetics
Telomere - metabolism
Telomere - physiology
Telomere Homeostasis - genetics
Telomere length maintenance
Telomere nuclear distribution
Telomere length maintenance
Telomere nuclear distribution
Telomere
Nuclear organization
Cancer
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Summary:Abstract Telomeres are crucial for the maintenance of genome stability through “capping” of chromosome ends to prevent their recognition as double-strand breaks, thus avoiding end-to-end fusions or illegitimate recombination [1–3] . Similar to other genomic regions, telomeres participate to the nuclear architecture while being highly mobile. The interaction of telomeres with nuclear domains or compartments greatly differs not only between organisms but also between cells within the same organism. It is also expected that biological processes like replication, repair or telomere elongation impact the distribution of chromosome extremities within the nucleus, as they probably do with other regions of the genome. Pathological processes such as cancer induce profound changes in the nuclear architecture, which also affects telomere dynamics and spatial organization. Here we will expose our present knowledge on the relationship between telomeres and nuclear architecture and on how this relationship is affected by normal or abnormal telomere metabolisms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2012.02.001