Glycosyl Phosphatidylinositol-Anchored T-Cadherin Mediates Calcium-Dependent, Homophilic Cell Adhesion

• Published in: The Journal of cell biology Vol. 119; no. 2; pp. 451 - 461
• Main Authors: Vestal, Deborah J., Ranscht, Barbara
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.10.1992; The Rockefeller University Press
• Subjects: Aggregation; Amino Acid Sequence; Animals; Antiserum; Biological and medical sciences; Cadherins; Cadherins - drug effects; Cadherins - genetics; Cadherins - metabolism; Calcium - pharmacology; Cell adhesion; Cell Adhesion - drug effects; Cell Adhesion - physiology; Cell adhesion molecules; Cell aggregates; Cell interactions, adhesion; Cell lines; Cell Membrane - chemistry; Cells; Cellular biology; CHO Cells; Conserved Sequence; Cricetinae; Cytochalasin D - pharmacology; Cytoskeleton - drug effects; Cytoskeleton - physiology; Fundamental and applied biological sciences. Psychology; Glycosylphosphatidylinositols - metabolism; Molecular and cellular biology; Molecular Sequence Data; Neurons; Nocodazole - pharmacology; Protein Precursors - drug effects; Protein Precursors - genetics; Protein Precursors - metabolism; Transfection; Trypsin - pharmacology; Type C Phospholipases - pharmacology; Morphogenesis; Regulation(control); Sensitivity; Calcium; Ions; Adhesion; Recognition

Cadherins are a family of cell adhesion molecules that exhibit calcium-dependent, homophilic binding. Their function depends on both an HisAlaVal sequence in the first extracellular domain, EC1, and the interaction of a conserved cytoplasmic region with intracellular proteins. T-cadherin is an unusu...