Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology

• Published in: Japanese journal of radiology Vol. 26; no. 8; pp. 488 - 493
• Main Authors: Azuma, Asako, Tozaki, Mitsuhiro, Ito, Kensuke, Fukuma, Eisuke, Tanaka, Tomoko, O’uchi, Toshihiro
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.10.2008; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Cancer; Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging; Carcinoma, Intraductal, Noninfiltrating - pathology; Cell density; Computed tomography; Density ratio; Female; Fluorodeoxyglucose F18; Histopathology; Humans; Imaging; Mapping; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Positron emission; Positron emission tomography; Radiology; Radiopharmaceuticals; Radiotherapy; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Statistical analysis; Tomography; Tomography, X-Ray Computed; Tumors; FDG-PET/CT; DCIS; Breast cancer
• ISSN: 0288-2043; 1867-1071; 1862-5274; 1867-108X
• DOI: 10.1007/s11604-008-0263-6

Purpose The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS). Materials and methods Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS. Results Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area. Conclusions Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT.