Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology
Purpose The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS). Materials and methods Subjects in this retrospective revi...
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Published in | Japanese journal of radiology Vol. 26; no. 8; pp. 488 - 493 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Springer Japan
01.10.2008
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS).
Materials and methods
Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS. Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS.
Results
Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area.
Conclusions
Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0288-2043 1867-1071 1862-5274 1867-108X |
DOI: | 10.1007/s11604-008-0263-6 |