Doubly stereoconvergent crystallization enabled by asymmetric catalysis
Synthetic methods that enable simultaneous control over multiple stereogenic centers are desirable for the efficient preparation of pharmaceutical compounds. Herein, we report the discovery and development of a catalyst-mediated asymmetric Michael addition/crystallization-induced diastereomer transf...
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| Published in | Science (American Association for the Advancement of Science) Vol. 376; no. 6598; pp. 1224 - 1230 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
10.06.2022
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| Online Access | Get full text |
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| Summary: | Synthetic methods that enable simultaneous control over multiple stereogenic centers are desirable for the efficient preparation of pharmaceutical compounds. Herein, we report the discovery and development of a catalyst-mediated asymmetric Michael addition/crystallization-induced diastereomer transformation of broad scope. The sequence controls three stereogenic centers, two of which are stereochemically labile. The configurational instability of 1,3-dicarbonyls and nitroalkanes, typically considered a liability in stereoselective synthesis, is productively leveraged by merging enantioselective Brønsted base organocatalysis and thermodynamic stereocontrol using a single convergent crystallization. The synthesis of useful γ-nitro β-keto amides containing three contiguous stereogenic centers is thus achieved from Michael acceptors containing two prochiral centers. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: P.d.J.C. and J.S.J. conceived the study. P.d.J.C., W.R.C., and J.S.J. designed, implemented, and analyzed the experiments. C.H.C. performed the x-ray diffraction studies. P.d.J.C., W.R.C., and J.S.J. wrote the manuscript. |
| ISSN: | 0036-8075 1095-9203 1095-9203 |
| DOI: | 10.1126/science.abo5048 |