Comment on “ILC1 drive intestinal epithelial and matrix remodeling”

Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. ( Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC...

Full description

Saved in:
Bibliographic Details
Published inMucosal immunology Vol. 14; no. 2; pp. 279 - 281
Main Authors Hariss, Fatima, Meresse, Bertrand
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.03.2021
Elsevier Limited
Nature Pub. Group
SeriesMucosal Immunology
Subjects
Allergology
Antibodies
Biomedical and Life Sciences
Biomedicine
Cadmium
Cell growth
Comment
Crohn's disease
Cytokines
Dendritic cells
Epigenetics
Fibroblasts
Gastroenterology
Gelatinase B
Glycoproteins
Immunology
Infections
Inflammation
Inflammatory bowel disease
Intestine
Intestines
Investigations
Killer Cells, Natural
Kinases
Life Sciences
Lymphoid cells
Metalloproteinase
Mucosa
Organoids
Pathogenesis
Physiology
Transforming growth factor-b1
Online AccessGet full text

Cover

More Information
Summary:Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. ( Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1933-0219
1935-3456
DOI:10.1038/s41385-020-00360-9